Effects of simvastatin on lipid profile and nerve conduction velocity in obese Sprague Dawley rats.
نویسندگان
چکیده
BACKGROUND The incidence of obesity is increasing worldwide. The lipid derangements and decrease in nerve conduction velocity are important complications for which a number of treatment options are being considered. In this study, Simvastatin, a hydroxyl methyl glutaryl coenzyme A reductase inhibitor is studied for its effects on these complications of obesity. METHODS The study was a randomised control trial conducted at Islamic International Medical College, Rawalpindi in collaboration with Railway General Hospital, Rawalpindi, and National Institute of Health, Islamabad. Ninety adult male Sprague Dawley rats were divided into three groups with thirty rats in each group. One group of rats was taken as control with normal diet while other two groups were given High Fat Diet (HFD) for the whole study period, i.e., 10 weeks. One of the HFD group was given Simvastatin along with high fat diet for four weeks. Lipid profile was done by enzymatic colorimetric method. Conduction velocity of sciatic nerve was determined with the help of PowerLab data acquisition system. RESULTS The two groups with HFD showed more than 25% increase in weight at the end of study as compared to control group. HFD group showed significantly higher lipid profile and decreased sciatic nerve conduction velocity when compared with control. The group that was given Simvastatin showed significant improvement in lipid profile and increased sciatic nerve conduction velocity after 4 weeks when compared with the group that was given HFD without any intervention. CONCLUSIONS Simvastatin is effective for improving the lipid profile and sciatic nerve conduction velocity in HFD induced obesity.
منابع مشابه
Effects of simvastatin and alpha-tocopherol on disturbed nerve conduction in obese Sprague Dawley rats.
BACKGROUND The incidence of obesity is increasing worldwide. The neuropathy associated with obesity, that is evident from disturbed nerve conduction, is one of the complications for which a number of treatment options are being considered. In this study, Simvastatin, a hydroxyl methyl glutaryl coenzyme A reductase inhibitor and alpha-tocopherol, a dietary antioxidant are compared for their effe...
متن کاملEvaluation of date extract on nerve conduction velocity in male rat
Abstract Introduction: neuropathy is a condition in which the peripheral nervous system is disrupted. The study of the effects of antioxidants on the performance improvement of this system is vital. This study was aimed at the investigation of the effects of date extract on nerve conduction velocity, distal latency, and wave height of the sciatic nerve in male rats. Materials and Methods: thi...
متن کاملEvaluating the effects of metformin on irisin and serum biochemical parameters in male sprague-dawley rats fed by a high-fat emulsion diet
Irisin is a myokine secreted mostly by muscles after exercise, and its secretion level changes in metabolic disorders. The aim of present study was to investigate the effect of metformin on changes in the levels of plasma irisin, blood glucose and insulin resistance in male Sprague-Dawley rats receiving a high-fat emulsion diet. Twenty-four rats were divided into a normal control group (n = 8) ...
متن کاملGallic acid and exercise training improve motor function, nerve conduction velocity but not pain sense reflex after experimental sciatic nerve crush in male rats
Objective: The aim of present study was to evaluate the effects of oral administration of gallic acid (GA) for 21 days alone and in combination with exercise on nerve conduction velocity and sensory and motor functions in rats with sciatic nerve crush. Materials and Methods: Seventy adult male Wistar rats (250-300 g) were divided randomly into 7 groups with 10 in each: 1) Control (Cont), 2) Cru...
متن کاملAn implantable electrical stimulator used for peripheral nerve rehabilitation in rats
This study evaluated an implantable electrical stimulator using a sciatic nerve injury animal model, and ethological, electrophysiological and histological assessments. Forty Sprague-Dawley rats were used in the study, and were subjected to crushing of the right sciatic nerve with a micro-vessel clamp. Electrical stimulators were implanted in twenty of the rats (the implantation group), while t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of Ayub Medical College, Abbottabad : JAMC
دوره 23 3 شماره
صفحات -
تاریخ انتشار 2011